![]() ![]() ![]() The stories in this book reflect the author's recollection of events. The disclaimer language goes something like this: You can explain that choice in a disclaimer at the beginning of your book. Remember, too, that you have the option to use some real names and some pseudonyms. Whatever feedback or advice you get, in the end you're the one who has to live with the decision and its consequences. If you have the good fortune to have sold your book to a publishing house, their legal department will take care of that part, vetting the manuscript before it goes to press.Įven if you paint a character in a glowing light, it's not a bad idea to have a conversation with him before publication, and be willing to show him the scenes in which he appears. This is where an attorney well-versed in publishing could come in handy. If Uncle Saul really does come off as a complete putz, you probably will want to change his name, and you may even need to alter recognizable traits or story elements. Steps to Take to Protect Yourself (And Those You Write About) Regardless of how you have portrayed the people in your memoir, if you use real names, or if the characters are otherwise recognizable, you may need to get signed permissions. Perhaps you think you've written Uncle Saul as a complete ogre, while your editor or friend finds him endearing. Hire an editor or enlist a trusted friend (trusted to be kind, but also to tell the truth) and ask her how she thinks you've portrayed a particular character. We're often far too close to our own writing (and our own story) to see it clearly. Before publishing your memoir, get feedback from others and, if necessary, consult an attorney. After completing the first draft or two, you might have more clarity on the pros and cons of using real names.ģ. Wait until you're ready to sit down to your second draft (or third or fourth) to decide what you're going to do about the name issue. Save the editing and decision making for a later draft.Ģ. The best way to write a first draft is to remove all censorship and pour it out onto the page. You (like most writers) already battle with enough resistance and procrastination when trying to write don't make it worse by censoring yourself. Write your first draft exactly as it happened, using all real names and places. The answer I usually give my clients comes in three parts:ġ. If, however, you'd rather not mention genitalia in your book, you're still left with the question: “Do I use their real names?” Real or Fictionalized Names? If anyone tries this tack, I'd love to hear how it works. ![]() Someone in the audience had asked the very question at hand about one particular character in his own memoir and, in true Lamott style, she answered: "Give the character a small penis." Once the laughter in the audience died down, someone else asked, “What if the character is a woman?” Without missing a beat, Lamott said, “Give the character a small penis.” (And you certainly don't want to end up getting sued for slander or libel.) So what do you do? Do you write your story as fiction? Do you move your town halfway across the country and rename all the characters? Do you change all recognizable traits?Īnne Lamott provided a hilarious answer at a reading I attended many years ago. If there's drama or conflict (and drama and conflict make for good storytelling), then at least one person was a jerk.īut just because someone behaved badly doesn't mean you want to ruin that person's life by exposing him in public. Perhaps you had a harrowing childhood or you escaped from an abusive relationship, or maybe you built your dream despite all the naysayers. Let's face it, you probably want to write about your life because it's been hard. These authors aren't worried about writing that Uncle Saul was an absolute angel. Of course, this question wouldn't arise if the people in my clients' lives had behaved nicely. None of us lives in a vacuum (except maybe a monk living in a cave in the Himalayas, but so far I haven't had any cave-dwelling monks as clients). You can't very well write about your life without writing about the people in your life. This is a question that gets asked every time I work with authors who are writing about their own lives. “Should I change the names of the people in my memoir?” ![]()
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![]() ![]() Chrome was "largely developed" in Google's Kitchener office. ĭevelopment of the browser began in 2006, spearheaded by Sundar Pichai. It also came shortly after the release of Mozilla Firefox 1.0, which was surging in popularity and taking market share from Internet Explorer, which had noted security problems. newspapers stated at the time that Google was hiring former Microsoft web developers among others. In September 2004, rumors of Google building a web browser first appeared. After co-founders Sergey Brin and Larry Page hired several Mozilla Firefox developers and built a demonstration of Chrome, Schmidt said that "It was so good that it essentially forced me to change my mind." He stated that "at the time, Google was a small company", and he did not want to go through "bruising browser wars". Google CEO Eric Schmidt opposed the development of an independent web browser for six years. Because of this success, Google has expanded the "Chrome" brand name to other products: ChromeOS, Chromecast, Chromebook, Chromebit, Chromebox, and Chromebase. Īs of October 2022, StatCounter estimates that Chrome has a 67% worldwide browser market share (after peaking at 72.38% in November 2018) on personal computers (PC), is most used on tablets (having surpassed Safari), and is also dominant on smartphones and at 65% across all platforms combined, making it the most used web browser in the world today. WebKit was the original rendering engine, but Google eventually forked it to create the Blink engine all Chrome variants except iOS used Blink as of 2017. Most of Chrome's source code comes from Google's free and open-source software project Chromium, but Chrome is licensed as proprietary freeware. ![]() The browser is also the main component of ChromeOS, where it serves as the platform for web applications. Versions were later released for Linux, macOS, iOS, and also for Android, where it is the default browser. It was first released in 2008 for Microsoft Windows, built with free software components from Apple WebKit and Mozilla Firefox. Google Chrome is a cross-platform web browser developed by Google. ![]() Proprietary freeware, based on open source components ![]() ![]() ![]() Unlike most other independent developers, we have no interest in building the next World of Warcraft or the next mainstream console FPS. The company reincorporated in 2021 following relocation. Visual Entertainment and Technologies LLC was conceptualized in August 2010, and incorporated in 2013, to fill the need for high-quality niche-market computer games. GearCity is VENT's first product of hopefully many more. The lack of quality in the genre and feeling the need for a modern version of Detroit or Motor City, Eric founded VENT to create high-quality hyper-realistic business sims. Hampered by bugs and quality issues, the game was a major flop. One of these tycoon games was Car Tycoon. ![]() For a brief period in the early 2000s, the success of Roller Coaster Tycoon brought forth a "Tycoon boom," which saw the market flooded with low-quality casual business sims. With the growth of 3d graphics, management sims slowly died out. Sadly the cons generally outweighed the pros. These two titles allowed you to take charge of a car company. Although neither game achieved blockbuster sales, they garnished a cult following and were moderately successful. The very next year, Max Design GesMBH released Motor City. If we can raise enough funds post-release, then there is a chance we'll get multiplayer.ĭuring the golden age of management games in 1994, Impressions Games released Detroit. The game was initially designed for multiplayer but went singleplayer only early in development. We believe this will make the game harder and more fun than typical Tycoon style games. Our fundamental goal is to create a realistic simulation of the economics that affect automobile manufacturers. The game also features approximately 300 AI competitors, a financial sector, and contracts/contracting. The "Realistic Economic Simulation Engine" processes vehicle and buyer pool, so customers find exactly the right car for them. These dealerships are the front line to the population. The game only allows one factory and branch per city.ĭealerships automagically appear based on the quality of your branch/service/sales. This data includes but is not limited to: population, per capita, manufacturing capacity, infrastructure, growth rates, and tax rates. All of them have historical data figures from 1900 to 2018. ![]() There are hundreds of cities in the game. With the world map, you'll control vehicle production, distribution, and marketing. It also is the focal point for human resources, union negotiation, charts/figures, news, lobbying, etc. The office is the main connection point to the other parts of the game. How will the business side of the game work?Įssentially, the game is run hub style much like Detroit and Motor City. We offer video tutorials on this and many other topics on the tutorials page. Once several months have passed, the engineers will complete the project, and the player has a useable vehicle. The player selects a vehicle type, the chassis, engine, and gearbox. You also set your desired dimensions, specs, and goals for your engineers to focus on.Īfter the components have been designed (and they all work together,) you can make a vehicle. The player controls the selection of key parts of the components. Vehicles in GearCity have three major components: Chassis, Engines, and Gearboxes. You can find the user manual in game by clicking "Help" and then "Wiki/Manual." Or you can find it here. The video tutorials are also accessable in game by clicking "Help" and then "Video Tutorials." You can find the video tutorials on our tutorials page or Youtube. We also have another two and half hours of interactive in-game tutorials that we suggest you try. The game has four and a half hours of video tutorials covering advanced topics in the game. We recommend you get something a little more powerful and 64-bit. *This is bare minimum support for 32-bit build. Windows XP or newer, OS X 10.7+, Linux glib 2.17 It entered Steam Early Access in May 2014, and it exited Early Access on January 14th, 2022.ġ28MB OpenGL 1.2 or DirectX 9 compatible Video Card We released Open Betas starting in March 2013. Or you can purchase and play the full version of the game from any one of these stores.ĭevelopment started in January 2010. You already can! There is a game turn limited demo. To do so you will need to build, design, sell, market, negotiate, and crush your competition. You have one simple goal, stay in business. ![]() Although, it is more complex and in-depth than ordinary tycoon games. GearCity is an automobile manufacturing business simulator, also known as a tycoon game. ![]() ![]() ![]() Browse our collection of ready made blinds from B&Q today. Our well-equipped facilities and excellent excellent management throughout all stages of creation enables us to guarantee total buyer satisfaction for Grey Zebra Blinds, Roller Blinds With Side Channels, Motorized Window Coverings, Outdoor Roller Window Blinds & Shades, One Way Window Covering. Showcase your individual aesthetic, protect your privacy, and enjoy autonomy over the sunlight in your space with ease, style, and a sprinkling of you. ![]() Provide the finishing touch to your home with window blinds. 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![]() ![]() The blood sample of a Bckdha −/− mice was insufficient for analysis. Source data are provided as a Source data file.Ī Weight curves and b plasma leucine concentrations at sacrifice ( Bckdha −/− injected with 10 13 vg/kg and sacrificed <4 weeks n = 2 (2 females), Bckdha −/− injected with 10 13 vg/kg and sacrificed at 4 weeks n = 5 (1 male/4 females), Bckdha −/− injected with 10 14 vg/kg and sacrificed at 4 weeks n = 2 (1 male/1 female), Bckdha +/− n = 18 (9 males/9 females), Bckdha +/+ n = 9 (2 males/7 females). d Western blot analyses of human BCKDHA in Huh7 cells transfected with hAAT GFP, hAAT iSV40 h BCKDHA WT, hAAT iSV40 h BCKDHA co1 (codon-optimized sequence 1), and hAAT iSV40 h BCKDHA co2 (codon-optimized sequence 2), the three of them carrying the SV40 intron ( n = 3 biological replicates for each condition). c AAV8-hAAT-h BCKDHA vector genome consisting of an expression cassette including hepatocyte-specific hAAT promoter composed of the ApoE enhancer and the human alpha 1 antitrypsin promoter (hAAT), a SV40 intronic sequence, the h BCKDHA coding sequence, a WPRE sequence and a polyadenylation signal (bGH poly(A)), flanked by AAV2 ITRs. b Western blot analyses of human BCKDHA in Huh7 cells transfected with EF1α GFP, EF1α h BCKDHA WT, EF1α h BCKDHA co1 (codon-optimized sequence 1) and EF1α h BCKDHA co2 (codon-optimized sequence 2) ( n = 3 biological replicates for each condition). ![]() Here we show efficacy of gene therapy for MSUD demonstrating its potential for clinical translation.Ī AAV8-EF1α-h BCKDHA vector genome consisting of an expression cassette including a ubiquitous human elongation factor 1-alpha promoter (hEF1a) with an extra intronic sequence, the h BCKDHA coding sequence, a WPRE sequence, and a polyadenylation signal (bGH poly(A)), flanked by AAV2 ITRs. While the use of a ubiquitous promoter fully and sustainably rescued the disease (long-term survival, normal phenotype and correction of biochemical abnormalities), liver-specific expression of BCKDHA led to partial, though sustained rescue. BCKDHA gene transfer rescued the lethal phenotype. Animals were treated at P0 with intravenous human BCKDHA AAV8 vectors under the control of either a ubiquitous or a liver-specific promoter. We establish and characterize the Bckdha (branched chain keto acid dehydrogenase a) -/- mouse that exhibits a lethal neonatal phenotype mimicking human MSUD. Here, based on significant liver contribution to the catabolism of the branched chain amino acid leucine, we develop a liver-directed adeno-associated virus (AAV8) gene therapy for MSUD. Treatment for MSUD represents an unmet need because the current treatment with life-long low-protein diet is challenging to maintain, and despite treatment the risk of acute decompensations and neuropsychiatric symptoms remains. syrup urine disease (MSUD) is a rare recessively inherited metabolic disorder causing accumulation of branched chain amino acids leading to neonatal death, if untreated. 13 Inserm UMR_S1163, Institut Imagine, Paris, France.
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![]() ![]() BUGFIX Improve auto index script to avoid calling function ini_set().BUGFIX Add more validation checks to avoid accidentally killing system process when stopping detached external application processes.BUGFIX Address a rare multi-threaded mod_security engine race condition.BUGFIX Address random crashes in mod_security engine.BUGFIX Address broken vhost level mod_security configuration.BUGFIX Address broken alt-python application caused by the new way virtualenv was built.TUNING Adjust internal shell scripts for better ubuntu compatibility.TUNING Do not enable cPanel HTTP server monitoring in update script.TUNING Enable suEXEC for PHP 8.1 by default.htaccess for early stage internal errors. IMPROVEMENT Support following ErrorDocument customizations in.IMPROVEMENT Add pagination for long auto indexed pages.IMPROVEMENT Better stale cache purge handling.IMPROVEMENT Add server level control to return 404 or 403 when directory auto-index is disabled.SECURITY Add more strict virtual host name validation in WebAdmin to address a potential XSS vulnerability.SECURITY Address a few crashes and memory leaks in HTTP/3 implementation.LSWS 6.0.12 Stable (05-12-2022) Securities, Improvements, Tunings & Bugfixes BUGFIX Fix domain limited licensing for Plesk servers.BUGFIX Fix connection timeout false-positives for active HTTP3 connections.BUGFIX Set "HOME" environment for CGI/External apps when possible.IMPROVEMENT Improve WebAdmin Console realtime stats with a new JavaScript library.IMPROVEMENT Detect update failures in lsup.sh.IMPROVEMENT Escape multiline STDERR messages.IMPROVEMENT Add Apache style configurations "LogKeepDays" and "LogCompressArchive".IMPROVEMENT Enhance 'disableCgiOverride' to cover options +ExecCGI and +Include.IMPROVEMENT Add "DisableForwardedIpBan" Apache style configuration directive to avoid blocking IPs forwarded by front-end proxies.IMPROVEMENT Configurable reCAPTCHA timeout.IMPROVEMENT Add conditional access logging using Expression.IMPROVEMENT Make SSI environment available to included CGIs/scripts.NEW FEATURE Trigger reCAPTCHA through mod_security engine via an environment variable.NEW FEATURE Apply OOMScoreAdjust for lsws service to avoid being OOM killed.NEW FEATURE Add custom response status code support.NEW FEATURE Add PROXY protocol support.LSWS 6.1 (01-09-2023) New Features, Improvements, Tuning & Bugfixes BUGFIX Address an issue with Plesk watchdog monitoring httpd service.BUGFIX Address an issue switching apache/lsws systemd unit file for Plesk.BUGFIX Fix broken sub-directory password protection configuration for Plesk WordPress toolkit.BUGFIX Fix SecRemoteRules certificate verification failure.BUGFIX Address a python application upload hang issue.BUGFIX Address a python application frequent restart issue.BUGFIX Address duplicate unique ID field in mod_security audit log.BUGFIX Address broken "RewriteOption inherit" corner case.BUGFIX Avoid blocking on socket read for internal fetcher.IMPROVEMENT Add support for "Require local" configuration directive.IMPROVEMENT Update WebAdmin Console login to use BCRYPT password hash.IMPROVEMENT Add support for unix domain socket for redis dynamic vhost.NEW FEATURE Add a vhost level AllowBlockedUrl option to allow blocked URL passthrough.NEW FEATURE Add SSL strict SNI mode option to fail SSL connections when there is no vhost level SSL certificate.LSWS 6.1.1 (04-12-2023) New Features, Improvements & Bugfixes ![]() |